http://www.chemistry-blog.com/2008/03/28/estrogen-analogues/ A Chat and Waffles Chemistry Blog Fri, 25 Jul 2008 01:11:36 +0000 http://wordpress.org/?v=2.5.1 http://www.chemistry-blog.com/2008/03/28/estrogen-analogues/#comment-608 Phil Mon, 31 Mar 2008 06:50:23 +0000 http://www.chemistry-blog.com/2008/03/28/estrogen-analogues/#comment-608 True, but a simple rotation won't do in this case. Something like a parallel shift is necessary, which would involve serious bending of the acetylene. True, but a simple rotation won’t do in this case. Something like a parallel shift is necessary, which would involve serious bending of the acetylene.

]]> http://www.chemistry-blog.com/2008/03/28/estrogen-analogues/#comment-578 Mitch Fri, 28 Mar 2008 18:03:52 +0000 http://www.chemistry-blog.com/2008/03/28/estrogen-analogues/#comment-578 The analogues not being rigid may actually be advantageous. Since there isn't 100% overlap in the structure, being able to rotate may supply that extra wiggle room needed for biological acivity. The analogues not being rigid may actually be advantageous. Since there isn’t 100% overlap in the structure, being able to rotate may supply that extra wiggle room needed for biological acivity.

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