Author Archive
Friday, May 16th, 2008
(190 Views)
You need to measure a 13C-NMR for all new compounds, that's a golden rule. But what do you do when you can't dissolve more than, say, 5 mg, of your stuff? Either you can't afford to dump more of it in DMSO, never to be seen again*, or it just ...
Posted in Uncategorized | 7 Comments »
Monday, April 21st, 2008
(255 Views)
This JACS communication by Danishefsky's group is inspired by the well-known Passerini 3-component (isonitrile + aldehyde + acid) and Ugi 4-component (isonitrile + aldehyde + amine + acid) reactions. They ask the question if isonitriles 1 react with carboxylic acids 2. At room temperature, they do not, but under microwave ...
Posted in synthetic chemistry | 1 Comment »
Friday, March 28th, 2008
(211 Views)
The authors of this paper (Chem. Eur. J. 2008, early view) have synthesized a series of new estrogen analogues where the B and C ring of estrone (1) and 17β-estradiol (2) are replaced with a simple alkyne spacer. The steric bulk of the omitted rings is replaced by suitable substitution ...
Posted in Uncategorized | 2 Comments »
Friday, February 22nd, 2008
(327 Views)
This ACIE article caught my attention. Here, a "click-chemistry" based approach is used for in vivo labeling of glycoproteins. The strained acetylene 1 is linked to biotin to give 2. Cells that have been cultured in a way as to introduce N-azidoacetylsialic acid into glycoproteins were exposed to acetylene 2, ...
Posted in science news | 2 Comments »
Tuesday, February 12th, 2008
(258 Views)
Hello!
My name is Phil. I'm doing my Ph.D. at ETH Zürich (that's right, in Switzerland), where I'm working in the field of Medicinal Chemistry. This is my first post, hooray!
One of my group jobs is to take care of the LC-MS system we bought last year. You know, that magic ...
Posted in Uncategorized | 1 Comment »
Carbon NMR Fail
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