Articles by: Chemjobber

Smart companies do smart things: Materia has a blog

So it’s not like anyone NEEDS encouragement to think about using olefin metathesis in their chemistry, but in case you wanted to talk to real experts, Materia (the company founded by Grubbs et al. to commercialize metathesis) has recently opened a blog called All Things Metathesis.

It’s got some literature reviews and stuff, but most helpful for chemists is the best practices category, where they explore how to plan your metathesis reactions and how best to purify them. So very 2003 to say this, but blogging is a great medium for businesses to communicate with their customers. This is a really nice example. They have comments, so you can even talk to metathesis experts!

So how long before there’s an Ask Dr. Metathesis column, where frustrated grad students write in with their late-night isomerization angst?

By November 3, 2009 1 comment chem 2.0

Milk? Sugar? Sodium azide?

458px-Sodium_azide According to a number of sources (including the Boston Herald and the New York Times), 6 people were sickened by drinking coffee laced with sodium azide at a lab at Harvard Medical School. Holy cow!

The press reports mention that (one of?) the victims feels that this wasn’t an accident. I think it’s interesting that one person passed out, but others reported low blood pressure and dizziness. My understanding of sodium azide is that it can be lethal, so it must have been a relatively low dose. (Thank God for small favors, huh?)

I don’t really know what to say about this, other than you have to be kind of a twisted individual to think this is a good solution to any sort of interpersonal problem you might be having.

(Credit for photo from Wikimedia.)

UPDATE: Changed a few words here and there for clarity.

By October 26, 2009 11 comments Uncategorized

Meth and mirror images: errors in Nick Reding’s “Methland”

meth-3

I recently picked up Nick Reding’s book Methland, which is about the blight of a small Iowa town due to methamphetamine use. I was interested in it because I had heard about it from NPR; I was interested in what Reding had to say about the chemistry of meth synthesis. What I found was pretty amusing.

I should pause to say that Reding was not focused on the chemistry at all — rather, his thesis was that meth was a mere symptom of the devastating effects of global economic forces on a small Iowa town. It’s well written and pretty gripping stuff.

I’m sure I’m not the only chemist who can get distracted by chemical explanations that’s just obviously wrong. But some of the explanations were just terribly, terribly wrong:

“Mirror imaging is a process whereby a chemical’s molecular structure is reversed, moving, for example, electrons from the bottom of a certain ring to the top, and vice versa. Pseudoephedrine, ephedrine, and methamphetamine are already near mirror images of one another. To make meth from ephedrine, it is necessary to remove a single oxygen atom from the outer electron ring. Thus ephedrine and methamphetamine not only look the same under a mass spectrometer, but both dilate the alveoli in the lungs and shrink blood vessels in the nose-hence ephedrine’s use as a decongestant while raising blood pressure and releasing adrenaline. The key difference is that meth, unlike ephedrine, prompts wide-scale releases of the neurotransmitters dopamine and epinephrine.

What the 1997 tests at the University of North Texas showed was that, at least in lab animals, mirror-image pseudoephedrine was equally as effective as regular pseudoephedrine as a decongestant. Unlike regular pseudo, however, the mirror-image version didn’t cause any side effects to the central nervous system, such as high blood pressure and a racing heart: the common “buzz” that one associates with cold medicine. Better yet for Warner-Lambert, mirror-image pseudoephedrine could only be synthesized into mirror-image methamphetamine, which, according to the Oregonian, had no stimulant effects and could not then be made into regular meth.” (quote thanks to Mike the Mad Biologist.)

Where to begin? First of all, “mirror imaging” is not a term; the word you’re looking for is, of course, enantiomers. The explanation about electrons is not correct; you can’t move electrons willy-nilly around rings. The comparison of ephedrine and methamphetamine as mirror images is wrong — they’re not even structural isomers. To make meth from ephedrine, you don’t “remove a single oxygen atom from the outer electron ring” (that sounds like something you do on the planet Zefu), you remove an oxygen and a hydrogen from a side chain by reduction. Ephedrine and methamphetamine most certainly DO NOT look the same under a mass spectrometer; I imagine it’s quite easy to distinguish the peaks from one another. Did Reding’s editor basically make a pass on the science stuff?

Reding’s book relies heavily on a series of articles on the meth epidemic written by Steve Suo of the Portland Oregonian. (If you look in Suo’s articles, you’ll see that Reding basically reworded the somewhat-more-correct chemistry explanation from Suo’s article.) Reding and Suo’s larger point  is that (-)-pseudoephedrine does not generate CNS-active methamphetamine, and that Warner-Lambert (and subsequently, Pfizer) were not interested enough in the larger public health issues to spend the money to push (-)-psuedoephedrine through the FDA approval process when the enantiomer they had was already quite lucrative.

So now that we’ve had a laugh about bad chemistry explanations, a question for everyone: how easy is it to get (-)-pseudoephedrine? The companies in India contacted by Suo said that they could supply ton quantities, no problem. I’m skeptical, but not that skeptical. Anyone out there know about this?

By October 20, 2009 8 comments general chemistry

Lab essentials

Lab must have?

Lab must have?

If you had to list 5 items that you would buy for yourself in the lab, what would they be?

If your professional life is in the lab, it’s probably worth it to invest a little bit of your own money for your personal happiness. (Make sure to mark them so people know they’re yours!) If it gets the job done a little bit faster and makes life just a tiny bit easier, it’s probably worth the money.

My 5 lab essentials?

1. A multitool, with at least a knife, Phillips tip and file. (At left, the Leatherman Wave.)

2. Black sharpie. (Duh.) Silver sharpies are helpful as well.

3. Comfy eyewear, so attractive to you that you’ll want them on.

4. Calculator — doing scientific notation calculations with someone else’s calculator stinks. Now where is that EXP button?!?

5. A nice pen — personally, I prefer the Uniball medium-to-fine tips. Writing in your notebook should be a pleasure.

What are your 5 lab must-haves?

(Thanks to Mitch for the invitation to the blog – I am honored.)

By September 16, 2009 20 comments Uncategorized