Chemistry Blog

Quintus

Author's details

Name: Stuart Mickel
Date registered: May 30, 2012

Latest posts

  1. Explosive Solutions — August 28, 2013
  2. When is a Proton not a Proton? — August 8, 2013
  3. Has Tamiflu got a cold? — February 16, 2013
  4. Molecular Mechanics — January 14, 2013
  5. The Seven (deadly) Sins of Science — December 9, 2012

Most commented posts

  1. Discovery chemist; 1,2 shift to a Development chemist — 12 comments
  2. Life in Chemical Development Part 1. — 9 comments
  3. Another Fascinating Structure and a Potent Anti-Cancer agent. (-)-FR 182877 — 8 comments
  4. Now we can’t drink tea! — 8 comments
  5. What’s in a name? — 7 comments

Author's posts listings

Aug 28

Explosive Solutions


mercury azides

Instead of starting at the beginning of a paper I want to kick off this commentary with a statement from near the end: “Caution! Covalent azides are potentially hazardous and can decompose explosively under various conditions! Especially Hg2(N3)2, α- and β-Hg(N3)2, and [Hg2N]N3 in this work are extremely friction/shock-sensitive and can explode violently upon the …

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Aug 08

When is a Proton not a Proton?


proton

A recent article in Accounts of Chemical research discusses this very topic as well as some other interesting facts revolving around protons, their structure and their generation. What does H+ signify? Well it means different things to different disciplines. If you are a physicist it refers to one of the fundamental elementary particles, if you …

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Feb 16

Has Tamiflu got a cold?


flu

Tamiflu, made by Roche and licensed by them from Gilead and stockpiled in many countries has proved to be a big money maker for Roche. It is one of two neuramidase inhibitors currently available for the treatment of influenza, the other being Zanamivir from Glaxo. Tamiflu is sold as its mono-phosphate salt. During the recent …

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Jan 14

Molecular Mechanics


Synthesising small molecular machines has been somewhat limited to making molecules that can walk or spin round cogwheels. Mind you that is still pretty impressive. Now things are set to change with a recent publication in Science by Dr Leigh from the University of Manchester in the UK. The Manchester group synthesised a rotaxane (a …

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Dec 09

The Seven (deadly) Sins of Science


Professor W. F. v. Gunsteren has written a very interesting essay for Angewandte entitled “The Seven Sins in Academic Behaviour in the Natural Sciences”. In this piece he defines the seven sins as follows (taken from the essay)   A poor or incomplete description of the work, for example, publishing pretty pictures instead of evidence of …

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Dec 05

The Flagship of Chemistry (Total Organic Synthesis).


In an essay to celebrate the 125th anniversary of Angewandte Chemie our friend and mentor Prof. K. C. Nicolaou had penned an essay for this august event. Which can be seen here. Not to be outdone in this essay he examines the flow of chemical knowledge from its emergence in the 5th century B.C. to …

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