Post Tagged with: "ACS Nano"

Alleged Data Manipulation in Nano Letters and ACS Nano from the Pease group

Leonard Pierce III

A recent paper from Rajasekhar Anumolu and Leonard F. Pease in Nano Letters entitled, “Chopstick Nanorods: Tuning the Angle between Pairs with High Yield“, had a collection of very interesting TEM images. Below are a set of images from both Figure 4E and 4F.

The images below show the boundary of one nanorod apparently overlapping the adjacent nanorod. This is not the only type of artifacts that are visible.

1 3 4
Adapted with permission from Nano Lett., Article ASAP (DOI: 10.1021/nl400959z). Copyright 2013 American Chemical Society.
In other parts of the same figure, nanorod boundaries seem to be obviously different colors than the surrounding background.

5 2
Adapted with permission from Nano Lett., Article ASAP (DOI: 10.1021/nl400959z). Copyright 2013 American Chemical Society.
Image manipulation does not seem confined to only this manuscript; in the supporting information of another paper in a different journal, this time in ACS Nano, entitled, Fabrication of Highly Uniform Nanoparticles from Recombinant Silk-Elastin-like Protein Polymers for Therapeutic Agent Delivery, Figure S2C looks to me to be manipulated. My eyes can find a grey square and a grey ellipse added to the image.

Adapted with permission from ACS Nano, 2011, 5 (7), pp 5374–5382 (DOI: 10.1021/nn103585f). Copyright 2011 American Chemical Society.
Both Professor Pease and Rajasekhar Anumolu were contacted two days prior to publishing this story for comment. Professor Pease informed me there was an investigation underway at the University of Utah into this matter and strongly encouraged me not to publish this story until the University completed its investigation. No comment was received from Rajasekhar Anumolu.

Prior to publishing this story Jeffrey R. Botkin, Associate Vice President for Research at University of Utah, contacted me confirming that “the University of Utah was informed of this matter by the editor of the journal and the University is conducting a thorough investigation for research misconduct.”

Update (8/15): Nano Lett paper is withdrawn.


By August 13, 2013 85 comments science news

Eating Carbon Nanotubes

Fathi Moussa

Lon Wilson

Last year I covered Khodakovskaya et al.’s paper regarding the benefits of growing tomatoes in carbon nanotubes (CNT).[CB] At the time I was concerned with the potential health risks associated from eating carbon nanotubes, but today in ACS Nano my concerns are alleviated. A paper from Lon Wilson’s and Fathi Moussa’s research groups discusses the effects from administering oral doses of carbon nanotubes (concentrations as high as 1g of CNT per kg body weight) to Swiss mice.[ACS Nano] The authors summarize their work the best.

CNT materials did not induce any abnormalities in the pathological examination. Thus, under these conditions, the lowest lethal dose (LDLo) is greater than 1000 mg/kg b.w. in Swiss mice.

So feel free to eat all the CNTs you want in lab, assuming they are not functionalized, you do it only once, and you limit yourself to single walled carbon nanotubes. I think partly because the results of the oral administration of CNTs went without any interesting side effects to present, the authors also looked into what happens when you inject CNTs into the peritoneal cavity of mice.

The image on the left is the control while the image on the right is 14 days after injecting mice with CNTs at a concentration of 1g CNT per kg of mouse. Although it looks sickly, the mice injected with the high concentration of CNTs did not die. Well…, not from the CNTs anyways.

Link to paper: In Vivo Behavior of Large Doses of Ultrashort and Full-Length Single-Walled Carbon Nanotubes after Oral and Intraperitoneal Administration to Swiss Mice (ACS Nano)


By February 23, 2010 9 comments chemical biology, materials chemistry

The Birth of NanoAgriculture

Mariya Khodakovskaya
Alexandru Biris

Update (5/30/13, azmanam): The paper referenced in this article was retracted in August 2012 for “unacceptable redundant inclusion of text and graphics from two works previously published in other journals.”

There has been a lot of concern over the health effects arising from the burgeoning field of nanotechnology, David Barden covered one such paper focusing on nanotube production in Highlights in Chemical Science earlier this month.[HCS] What hasn’t been as discussed are the potential health benefits of carbon nanotubes (CNTs). In a paper released yesterday in ACS Nano, Mariya Khodakovskaya & Alexandru Biris (+coauthors) found that tomato seeds grown in a medium of carbon nanotubes germinated and grew more efficiently than their control group brethren.[ACS Nano] This result is spectacularly seen from the image below.

After 27 days of growth.

The tomatoes grown in carbon nanotubes weighed more, grew longer stems, and matured faster. The authors reason this is due to the carbon nanotubes facilitating water intake, however the evidence provided doesn’t prove this beyond a reasonable doubt. Although I wouldn’t recommend eating these tomatoes just yet, one could still use the increase in plant biomass and efficiency for biofuels and related projects.

Link to paper: Carbon Nanotubes Are Able To Penetrate Plant Seed Coat and Dramatically Affect Seed Germination and Plant Growth


By September 23, 2009 7 comments chemical biology, materials chemistry