Chemistry Blog

Tag Archive: anti-cancer

Sep 15

From Natural Product to Pharmaceutical.


In a recent discussion (Nicolau), about the suggested move of Prof. NicoIau from Scripps, the issue of the practicality of natural product total synthesis was raised. Here is a wonderful example of just that very usefulness, a wonderful piece of science extending over many years. It concerns the journey from Halichondrin B to Eribulin (E7389) …

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Aug 22

Another Fascinating Structure and a Potent Anti-Cancer agent. (-)-FR 182877


(-)-FR 182877 and (-) FR 182876 are two structures isolated from Streptomyces sp. No.9885 by researchers at the Fujisawa Pharmaceutical company (now Astelllas)1-5. These compounds have been known for several years and the academic community has developed various approaches to their total synthesis, for example, references 6 and 7. Nakada etal8 became interested in the …

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Jul 05

A Bottle a Day keeps the Aging Away


Following on from the tea party where polyphenols reared their (ugly) heads a “highlight” has appeared in Angewandte Chemie English edition1, 2 pointing out the benefits of red wine, i.e. resveratrol. This is a well-known molecule, which has been at the centre of some controversy of late. Resveratrol is chemically trans3,5,4’-trihydroxystilbene: This compound can be …

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