Chemistry Blog

Tag Archive: Diels-Alder Reaction

Aug 22

Another Fascinating Structure and a Potent Anti-Cancer agent. (-)-FR 182877


(-)-FR 182877 and (-) FR 182876 are two structures isolated from Streptomyces sp. No.9885 by researchers at the Fujisawa Pharmaceutical company (now Astelllas)1-5. These compounds have been known for several years and the academic community has developed various approaches to their total synthesis, for example, references 6 and 7. Nakada etal8 became interested in the …

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Sep 26

Blog Carnival: The Diels-Alder Reaction!

The Diels-Alder Reaction

This post was excerpted and featured in a recent edition of C&ENews — No reaction is more elegant, more heartwarmingly satisfying than the Diels-Alder reaction.  No reaction is also more nuanced.  It appears deceptively simple and yet has the ability to create immense structural complexity often without additional reagents and sometimes solvent-free.  Straightforward enough for …

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