Chemistry Blog

Tag Archive: Pascal cyclization

Oct 17

Problems with Aryl Enediyne Cyclizations?


bergman

Enediynes are lovely functional groups that are famous for undergoing Bergman cyclizations as shown below. Scheme 1. Bergman cyclization. Vavilala et al. have found an alternate reaction pathway for thermal enediyne cyclizations when bulky aryl groups are attached to the terminal ends; they observed indene formation. Scheme 2. Pascal cyclization anyone? Making indenes from enediynes …

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